Luteinizing hormone increases platelet-derived growth factor-D gene expression in human granulosa–luteal cells

We aimed to investigate the effects of LH and FSH on the gene expression of the platelet-derived growth factor (PDGF) gene family in human granulosa–luteal cells. We found that LH significantly increased PDGF-D messenger RNA (mRNA) expression but suppressed PDGF-B and PDGF-C mRNA in human granulosa–luteal cells, and FSH also increases PDGF-D gene expression, but to a lesser extent.