کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3936505 1253450 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A novel “delayed start” protocol with gonadotropin-releasing hormone antagonist improves outcomes in poor responders
ترجمه فارسی عنوان
یک رمان یک ستاره با تأخیر؟ پروتکل آنتاگونیست هورمون آزاد کننده گنادوتروپین باعث بهبود نتایج در پاسخگوهای ضعیف می شود
کلمات کلیدی
شروع با تاخیر، پاسخگو ضعیف تحریک تخمدان کنترل شده است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

ObjectiveTo investigate whether delaying the start of ovarian stimulation with GnRH antagonist improves ovarian response in poor responders.DesignRetrospective study.SettingAcademic medical center.Patient(s)Thirty patients, who responded poorly and did not get pregnant with conventional estrogen priming antagonist IVF protocol.Intervention(s)Delayed-start antagonist protocol (estrogen priming followed by early follicular-phase GnRH antagonist treatment for 7 days before ovarian stimulation).Main Outcome Measure(s)Number of dominant follicles and mature oocytes retrieved, mature oocyte yield, and fertilization rate.Result(s)The number of patients who met the criteria to proceed to oocyte retrieval was significantly higher in the delayed-start protocol [21/30 (70%)] compared with the previous conventional estrogen priming antagonist cycle [11/30 (36.7%)]. The number of dominant follicles was significantly higher in the delayed-start (4.2 ± 2.7) compared with conventional (2.4 ± 1.3) protocol. In patients who had oocyte retrieval after both protocols (n = 9), the delayed start resulted in shorter ovarian stimulation (9.4 ± 1.4 days vs. 11.1 ± 2.0 days), higher number of mature oocytes retrieved (4.9 ± 2.0 vs. 2.2 ± 1.1), and a trend toward increased fertilization rates with intracytoplasmic sperm injection (ICSI; 86 ± 17% vs. 69 ± 21%) compared with conventional protocol. After delayed start, the average number of embryos transferred was 2.8 ± 1.4 with implantation rate of 9.8% and clinical pregnancy rate of 23.8%.Conclusion(s)The delayed-start protocol improves ovarian response in poor responders by promoting and synchronizing follicle development without impairing oocyte developmental competence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 101, Issue 5, May 2014, Pages 1308–1314
نویسندگان
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