کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3936886 1253463 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of CO2 insufflation-desufflation attacks on tissue oxidative stress markers during laparoscopy: a rat model
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The effect of CO2 insufflation-desufflation attacks on tissue oxidative stress markers during laparoscopy: a rat model
چکیده انگلیسی

ObjectiveTo determine the effects of sudden intra-abdominal pressure (IAP) changes on the terminal ileum in a pneumoperitoneum model.DesignAn experimental controlled study.SettingUniversity hospital in Turkey.Animal(s)Thirty-two adult female Sprague-Dawley rats.Intervention(s)The rats were divided into four groups. Group 1 was not subjected to IAP. In group 2, IAP insufflation was performed continuously to keep the IAP at 10 mmHg. Groups 3 and 4 underwent an insufflation-desufflation procedure: group 3 was fluctuated 5 times, and group 4 was fluctuated 10 times within the pneumoperitoneum period of 60 minutes. Thirty minutes after the desufflation, the terminal ileum was removed for the measurement of tissue malondialdehyde (MDA) values and histopathological examination.Main Outcome Measure(s)The tissue MDA values and histopathological damage scores.Result(s)The tissue MDA values in the IAP groups (groups 2, 3, and 4) were significantly increased when compared with those of the control group. The mean MDA value in group 4 was higher than that in groups 2 and 3. Histopathologic oxidative damage scores in the mucosa and submucosal layers were significantly higher in groups 2 and 3, compared with those of the control group. However, the highest histopathologic damage scores were observed in group 4.Conclusion(s)Unexpected desufflation-insufflation even at normal IAP levels during laparoscopy leads to significant oxidative stress–induced damage in the terminal ileum.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 92, Issue 1, July 2009, Pages 363–368
نویسندگان
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