کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3937122 | 1253473 | 2012 | 5 صفحه PDF | دانلود رایگان |
ObjectiveTo investigate the effect of stopping progesterone (P) support at week 5 versus week 8 on ongoing pregnancy rate after in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI).DesignProspective, randomized, controlled trial.SettingUniversity-affiliated infertility center.Patient(s)A total of 220 patients with intrauterine pregnancy demonstrated by transvaginal ultrasound after IVF/ICSI.Intervention(s)Luteal phase support with micronized vaginal P was suspended at week 5 or at week 8.Main Outcome Measure(s)Ongoing pregnancy rate, miscarriage rate, and number of bleeding episodes.Result(s)Progesterone levels were similar on the day of the first pregnancy ultrasound exam (149 ± 108 vs. 167 ± 115 ng/mL). Significantly more bleeding episodes were observed in the first trimester in the group with early cessation of P supplementation (18.0 ± 2.6 vs. 7.2 ± 1.3 episodes). Miscarriage rates among singleton pregnancies were similar in the two groups (5/80 vs. 6/79).Conclusion(s)Vaginal P supplementation after IVF/ICSI can be safely withdrawn at 5 weeks' gestation, because cycle outcome was similar to conventional luteal phase support up to 8 weeks of pregnancy.Clinical Trial Registration NumberNCT01177904.
Journal: Fertility and Sterility - Volume 98, Issue 4, October 2012, Pages 858–862