Improvement of hyperandrogenism and hyperinsulinemia during pregnancy in women with polycystic ovary syndrome: possible effect in the ovarian follicular mass of their daughters

ObjectiveTo evaluate the ovarian function during early infancy in daughters of women with polycystic ovary syndrome (PCOS) treated with metformin throughout pregnancy (PCOSd+M), as a means to reduce androgen and insulin levels, compared with daughters of nontreated PCOS women (PCOSd−M) and daughters of women who belong to a healthy comparison group (HCd).DesignDescriptive and analytic study.SettingUnit of endocrinology and reproductive medicine.Patient(s)Fifteen PCOSd+M, 23 PCOSd−M, and 35 HCd were studied at 2–3 months of age.Intervention(s)A GnRH analogue test was performed with determinations of gonadotropins, sex steroids, SHBG, and anti-Müllerian hormone (AMH).Main Outcome Measure(s)Differences in AMH levels between PCOSd+M, PCOSd−M and HCd.Result(s)AMH and peak E2 concentrations were significantly higher in PCOSd−M compared with HCd, whereas PCOSd+M exhibited AMH concentrations and peak E2 levels similar to those observed in HCd.Conclusion(s)The improvement of the altered endocrine-metabolic environment of PCOS mothers reduces AMH levels in their daughters, which might reflect a decrease in their follicular mass.