کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3937788 1253498 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hormone-induced delayed ovulation affects early embryonic development
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Hormone-induced delayed ovulation affects early embryonic development
چکیده انگلیسی

ObjectiveTo analyze the effects of delayed ovulation on embryonic development in mice, because intrafollicular oocyte development may be delayed during assisted reproductive technology (ART) treatment in humans.DesignExperimental mouse study.SettingUniversity hospital.Animal(s)Female C57Bl/6 mice.Intervention(s)Cetrorelix is used as a GnRH-antagonist in ART treatments. To assess the effect of delayed ovulation on embryonic development, cetrorelix was applied concomitantly with follicle stimulation by pregnant mare serum gonadotropin. Ovulation was induced by hCG. Controls were stimulated with pregnant mare serum gonadotropin without delaying ovulation. Suppression of ovulation was assessed from the number of tertiary follicles, ruptured follicles, and corpora lutea in mouse ovaries after cetrorelix treatment. Number and weight of embryos and placentas, as well as number of resorption sites and dead embryos, was determined on day 17.5 of pregnancy.Main Outcome Measure(s)Inhibition of ovulation, embryonic development.Result(s)Cetrorelix inhibited ovulation in mice, as shown by an increase in number of tertiary follicles concomitant with a significant inhibition of follicle rupture and corpora lutea formation. Delayed ovulation caused by Cetrorelix treatment led to a significant increase in resorption sites and a significant decrease in embryonic weight of offspring.Conclusion(s)Preovulatory oocyte overripeness might have an effect on fertility and embryonic development during ART treatment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 95, Issue 7, June 2011, Pages 2390–2394
نویسندگان
, , , ,