کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3937981 | 1253503 | 2011 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Increased expression of tuberin in human uterine leiomyoma
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Increased expression of tuberin in human uterine leiomyoma Increased expression of tuberin in human uterine leiomyoma](/preview/png/3937981.png)
چکیده انگلیسی
Female Eker rats harboring an insertional deletion in one copy of the tuberous sclerosis complex 2 (Tsc2) gene develop uterine leiomyoma, but the underlying mechanism of human uterine leiomyoma is not completely understood. To examine whether down-regulation of tuberin, a TSC2 gene product, is present in human uterine leiomyoma, we analyzed leiomyoma and matched myometrium tissues from 22 Chinese patients with Western blotting and real-time polymerase chain reaction analyses, and found that the expression of tuberin was significantly increased in leiomyoma tissues compared with matched myometrium tissues with inhibition of both the mammalian target of rapacmycin pathway and mitogen-activated protein kinase pathways.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 95, Issue 5, April 2011, Pages 1805–1808
Journal: Fertility and Sterility - Volume 95, Issue 5, April 2011, Pages 1805–1808
نویسندگان
Lihua Cui, Yuanyuan Ren, Hao Yin, Yuebing Wang, Dong Li, Meng Liu, Yingjun Zhu, Wanjun Lin, Xiang D. Tang, Yu Gui, Xi-Long Zheng,