کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3938168 1253513 2010 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-Müllerian hormone and inhibin B variability during normal menstrual cycles
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Anti-Müllerian hormone and inhibin B variability during normal menstrual cycles
چکیده انگلیسی

ObjectiveTo describe anti-Müllerian hormone (AMH) variation across normal menstrual cycles.DesignCohort study.SettingAcademic environment.Patient(s)Twenty regularly menstruating women.Intervention(s)Serum AMH and inhibin B assayed daily during one normal menstrual cycle.Main Outcome Measure(s)Intracycle variability of AMH and inhibin B.Result(s)Data were classified into quartiles of AMH area-under-the-curve (AUCs). Mean AMH AUC was 15.7 ng/mL for quartile 1 versus 43.5, 80.9 and 144.9 ng/mL for quartiles 2, 3, and 4. Mean AMH levels (ng/mL) were 0.67, 1.71, 3.02, and 5.33, respectively. There was no variation in quartile 1 AMH rate of change from stochastic modeling, but in quartiles 2 to 4, there were increased rates of change in days 2 to 7. Women in quartile 1 had the lowest mean inhibin B (24.2 pg/mL vs. 44.3, 43.2, and 42.2 pg/mL), and had shorter menstrual cycles (24.6 days) than women in quartiles 3 and 4 (28.2 and 28.4 days).Conclusion(s)There were two menstrual cycle patterns of AMH. The “aging ovary” pattern included low AMH levels with little variation, lower inhibin B, and shorter cycle lengths. The “younger ovary” pattern included higher AMH levels with significant variation days 2 to 7, suggesting that for women with AMH >1 ng/mL, the interpretation of AMH levels is contingent upon the day of the menstrual cycle on which the specimen is obtained.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 94, Issue 4, September 2010, Pages 1482–1486
نویسندگان
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