Association of blood type and patient characteristics with ovarian reserve

ObjectiveTo assess whether blood type was associated with diminished ovarian reserve (DOR) (day-3 follicle-stimulating hormone level >10 IU/L), controlling for history of tobacco smoking, body mass index (BMI), history of endometriosis, ovarian surgery, previous pregnancy, and maternal age.DesignCross-sectional study.SettingAcademic medical center, Division of Reproductive Endocrinology and Infertility.Patient(s)Women undergoing in vitro fertilization (IVF) from 2006–2011 (n = 305).Intervention(s)None.Main Outcome Measure(s)Presence of DOR in relation to a patient's blood type.Result(s)Other investigators have reported an increased risk for DOR in patients with blood type O and a protective effect on ovarian reserve for blood type A. We observed no association between a woman's blood type and DOR. We found an increased risk for DOR in patients aged 35 and older. Obesity (BMI ≥30 vs. BMI <25) was associated with lower odds of DOR.Conclusion(s)In comparison with blood type A, blood type O is not associated with an increase in DOR. We found no clinical implications for using blood type as a risk factor for DOR.