کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3939181 1253553 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Drugs in infertility and fetal safety
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Drugs in infertility and fetal safety
چکیده انگلیسی

ObjectiveTo evaluate the safety of drugs used in infertility treatment.DesignLiterature search using the keywords birth defect, congenital malformation, clomiphene, aromatase inhibitor, letrozole, gonadotropin, metformin, gonadotropin releasing hormone agonist and antagonist, progesterone, progestin, and estrogen. We conducted the search in Medline, EMBASE, and Cochrane Database of systematic reviews.Result(s)The available data suggest that clomiphene treatment, especially after several cycles, might be associated with a slightly higher risk of neural tube defects and severe hypospadias in the offspring. Letrozole and metformin do not appear to be teratogenic. The existing data concerning gonadotropin preparations suggest that there is no evidence of teratogenicity, yet, information after 1991 is lacking. Micronized progesterone, which is widely used in in vitro fertilization treatment, does not appear to increase the risk of nongenital birth defects; however, there might be a possible weak association between other progestational agents and hypospadias.Conclusion(s)Infertility per se is a risk factor for congenital anomalies. Repeated clomiphene treatment might be associated with a slightly higher risk of hypospadias and neural tube defect. However, the overall increased risk related to various fertility drugs is only 1% to 2%.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 89, Issue 6, June 2008, Pages 1595–1602
نویسندگان
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