Association study between single nucleotide polymorphisms in the VEGF gene and polycystic ovary syndrome

ObjectiveTo investigate single nucleotide polymorphisms (SNPs) in vascular endothelial growth factor (VEGF) gene that have significant associations with the pathogenesis of polycystic ovary syndrome (PCOS) in a Korean population.DesignCase-control study.SettingUniversity-based hospital.Patient(s)One hundred thirty-four patients with PCOS and 100 healthy women as controls.Intervention(s)None.Main Outcome Measure(s)Frequencies of genotypes for SNPs in VEGF gene, which were specifically expressed in a Korean population.Result(s)After genotypic analysis, we found that among 10 SNPs, one novel SNP at site +9812 and one known SNP at site +13553 have P values lower than .05 (+9812: odds ratio [95% confidence interval] 0.61 [0.39–0.95]; +13553: odds ratio [95% confidence interval] 0.59 [0.37–0.93]) and one haplotype (ht4) also has a P value in the significant range (odds ratio [95% confidence interval] 0.34 [0.16–0.74]).Conclusion(s)We concluded that one novel SNP at +9812 site, one known SNP at +13553 site, and one selected haplotype in the VEGF gene have a high possibility of significant associations with the pathogenesis of PCOS in a Korean population.