کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3939887 1253572 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The natural history of endocrine function and spermatogenesis in Klinefelter syndrome: what the data show
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The natural history of endocrine function and spermatogenesis in Klinefelter syndrome: what the data show
چکیده انگلیسی

Once thought to be a chromosomal aberration associated with absolute sterility, Klinefelter syndrome may now be potentially treatable by testicular sperm retrieval coupled with intracytoplasmic sperm injection. With these therapeutic advances, azoospermic 47,XXY men now may have an opportunity for biological paternity. However, our knowledge of the basic mechanisms underlying germ cell loss and Leydig cell compromise is lagging, and is just now beginning to evolve and provide answers to some of the field's most vexing questions: how to maximize and preserve fertility in Klinefelter males many years or even decades before they wish to actively pursue fatherhood. This article reviews the development of the androgenic and spermatogenic compartments of the Klinefelter testis through puberty, and recommends that it is only with a clear understanding of the basic facts that a rational, considered approach to fertility optimization and preservation can be determined.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 98, Issue 2, August 2012, Pages 266–273
نویسندگان
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