کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3940361 1253585 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Polymorphism in HSD17B6 is associated with key features of polycystic ovary syndrome
چکیده انگلیسی

ObjectiveTo investigate polymorphisms in androgen metabolism regulators that are implicated in the etiology of polycystic ovary syndrome (PCOS) in vitro; to investigate HSD17B6 and GATA6 to determine whether these genes are associated with susceptibility to PCOS or key phenotypic features of patients with PCOS.DesignCase–control association study.SettingParticipants with PCOS were recruited from a clinical-practice database, and controls, from the general community.Patient(s)One hundred seventy-three patients with PCOS and who were of Caucasian descent and conformed to the National Institutes of Health (NIH) diagnostic criteria; 107 normally ovulating women of Caucasian descent from the general community.Intervention(s)Drawing of blood for DNA extraction.Main Outcome Measure(s)Frequency of HSD17B6 and GATA6 polymorphisms in cases and controls. Association of single-nucleotide polymorphisms from HSD17B6 in subjects with PCOS with key phenotypes of PCOS: androgen status, insulin resistance, and body mass index.Result(s)Allele distribution for the single-nucleotide polymorphism rs898611 in HSD17B6 was significantly different between PCOS and control subjects (P=.03). Presence of the polymorphic allele was associated with reduced fasting glucose–insulin ratio (P=.02) and increased homeostasis model assessment (P<.01) and body mass index (P<.001) as well as with reduced T (P=.03) in the PCOS group. No association was seen between GATA6 and any of the variables studied.Conclusion(s)These data suggest that polymorphisms in the HSD17B6 gene are associated with PCOS and key clinical phenotypes of the disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 86, Issue 5, November 2006, Pages 1438–1446
نویسندگان
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