کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3940554 1253590 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ovarian stimulation with daily late follicular phase administration of low-dose human chorionic gonadotropin for in vitro fertilization: a prospective, randomized trial
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Ovarian stimulation with daily late follicular phase administration of low-dose human chorionic gonadotropin for in vitro fertilization: a prospective, randomized trial
چکیده انگلیسی

ObjectiveEvaluate the effectiveness of a new ovarian stimulation (OS) protocol before IVF.DesignProspective clinical randomized trial.SettingPrivate centers.Patient(s)Three hundred and twenty-three intended-to-treat women candidates for IVF.Intervention(s)Patients were divided into three groups and administered the following treatments: group A, recombinant hFSH from day 3 until follicles reached 13–14mm, when recombinant hFSH was lowered to 75 IU daily and daily injections of 200 IU of hCG and a GnRH antagonist were administered until final maturation; group B, recombinant hFSH and a GnRH antagonist; group C, recombinant hFSH and a GnRH agonist.Main Outcome Measure(s)Primary outcome was the number of mature oocytes. Secondary outcomes included average initial and total recombinant hFSH dosage, serum E2 level on day of ovulation, number of oocytes retrieved, fertilization, number of top-quality embryos, endometrial thickness, implantation rate, pregnancy rate (PR), and incidence of ovarian hyperstimulation syndrome (OHSS).Result(s)The numbers of oocytes retrieved, mature oocytes, fertilization, top-quality embryos, and embryos transferred were comparable in all groups. Implantation rate, PR, and incidence of OHSS were also comparable. The total dose of recombinant hFSH was significantly lower in group A (1,674.7 ± 59.4 IU, vs. 2,197.9 ± 77.8 IU in group B and 2,156.7 ± 80.9 IU in group C).Conclusion(s)This new OS protocol permits follicles and oocytes to fully develop, helps generate top-quality embryos, avoids premature ovulation, establishes clinical pregnancies, reduces administration of recombinant hFSH, minimizes costs, and does not increase the chances of OHSS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 86, Issue 4, October 2006, Pages 830–838
نویسندگان
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