کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3940917 1253598 2006 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Embryonic karyotype in recurrent miscarriage with parental karyotypic aberrations
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Embryonic karyotype in recurrent miscarriage with parental karyotypic aberrations
چکیده انگلیسی

ObjectiveTo assesses chromosomal aberrations in the abortus in recurrent miscarriage, in the presence of parental chromosomal aberrations.DesignRetrospective comparative cohort study.SettingTertiary referral unit in university hospital.Patient(s)One thousand one hundred eight patients with 3–16 miscarriages before 20 weeks gestation; 113 patients with and 995 without chromosomal aberrations.Intervention(s)Karyotyping by standard G-banding techniques of both parents, and of 205 abortuses collected at curettage.Main Outcome Measure(s)The incidence of the euploidic and aneuploidic abortuses according to the parental karyotype.Result(s)Two hundred three abortuses were successfully karyotyped. In 164 embryos of patients with no parental chromosomal aberrations, 23.2% (38/164) had chromosome aberrations. Of the 39 abortuses karyotyped in patients with chromosomal aberrations, 17 had normal karyotypes, 8 had balanced translocations, 2 had inversions identical to the parents, and 12 (30.8%) had abnormal karyotypes. This difference is not statistically significant (odd ratio 1.47, 95% confidence interval 0.63–3.39). Only 4 of the 39 karyotyped abortuses had an unbalanced translocation.Conclusion(s)Parental karyotyping was not particularly predictive of a subsequent miscarriage as a result of chromosomal aberrations as 43.5% of abortuses were euploidic, and the parental aberration was only passed on to the abortus in 10% of cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 85, Issue 2, February 2006, Pages 446–450
نویسندگان
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