کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3941072 1253602 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Bone morphogenetic protein 15 expression in human ovaries from fetuses, girls, and women
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Bone morphogenetic protein 15 expression in human ovaries from fetuses, girls, and women
چکیده انگلیسی

ObjectiveTo investigate, for the first time, the protein expression of bone morphogenetic protein (BMP) 15 in human ovaries from fetuses, girls/women as well as its mRNA transcripts in ovaries from fetuses and girls.DesignControlled immunohistochemical and in situ hybridization study of expression of BMP-15 protein and mRNA transcripts in human ovaries.SettingMajor tertiary care academic center.Patient(s)Nine patients that underwent pregnancy terminations at 21–33 gestational weeks and 18 girls and women aged 5–39 years that underwent ovarian laparoscopies.Intervention(s)None.Main Outcome Measure(s)Immunohistochemistry (protein detection) in all specimens and in situ hybridization (mRNA detection) in specimens from fetuses and girls. Both procedures were conducted on paraffin sections.Result(s)The expression of the BMP-15 protein and its mRNA was identified already from primordial stages. Protein expression was detected in all oocytes and stroma cells from both ovarian sources, and in granulosa cells of specimens from girls and women. The mRNA transcripts were detected in the oocyte, granulosa, and stroma cells from fetuses and girls.Conclusion(s)The BMP-15 protein is expressed already at primordial stages in fetuses, girls, and women, and its mRNA transcripts in fetuses and girls. Further studies should be conducted to elucidate if indeed BMP-15 is involved in the activation of human primordial follicles.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fertility and Sterility - Volume 92, Issue 5, November 2009, Pages 1666–1673
نویسندگان
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