Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas

Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated—estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.