Single nucleotide polymorphism in exon 17 of the insulin receptor gene is not associated with polycystic ovary syndrome in a Korean population

ObjectiveTo assess the association between the single nucleotide polymorphism of the insulin receptor (INSR) gene and polycystic ovary syndrome (PCOS) in a Korean population.DesignCase-control study.SettingUniversity-based hospital.Patient(s)One hundred seventy-four patients with PCOS and 93 healthy women as controls.Main Outcome Measure(s)Frequency of three genotypes for single nucleotide polymorphism found in exon 17 of INSR gene.Result(s)The high frequency of the T allele was shown both in patient and control groups. The frequency of C allele, which known as a normal allele, was slightly higher in the patient group than in the control group.Conclusion(s)The C/T polymorphism in exon 17 of the INSR gene is not associated with susceptibility of PCOS in a Korean population.