Predictors of residual carcinoma or carcinoma-in-situ at hysterectomy following cervical conization with positive margins

• We hypothesized that factors in the conization specimen predict residual disease at hysterectomy.
• In squamous histology, positive ECC, combined positive endocervical margin and ECC and disease volume ≥ 50% predicted residual disease at hysterectomy.
• In glandular histology, no conization characteristics studied were predictive of residual disease at hysterectomy.

ObjectivesIdentify predictors of residual carcinoma or carcinoma-in-situ (CIS) at hysterectomy following cervical conizations with CIS and positive margins or endocervical curettage (ECC) or microinvasive cervical cancer.MethodsPatients with cervical conization with CIS and positive margins, ECC or microinvasive carcinoma who underwent hysterectomy within 6 months of conization were identified. Conization and hysterectomy specimens were re-reviewed to assess volume of disease, ECC and margin status and residual carcinoma. Standard statistical tests were used.Results83 patients were included. 34 (41%) had residual carcinoma in the hysterectomy specimen: 23 CIS, 9 microinvasive and 2 invasive disease. In patients with squamous histology predictors of residual disease included a positive ECC (p = 0.04), combined endocervical margin and ECC (69% if both positive, 38% either positive, 11% if both negative, p = 0.01) and volume of disease ≥ 50% (p = 0.01). In patients with glandular histology no factor predicted residual disease. Type of conization, > 2 involved quadrants, and the presence of microinvasion in the conization specimen did not predict residual disease. No patient with squamous histology had > Stage IA1 disease at hysterectomy, whereas 2 (2.4%) with adenocarcinoma had > Stage IA1 disease at hysterectomy.ConclusionsResidual carcinoma or CIS is present in nearly half of hysterectomies after conization with CIS and positive ECC, margins or microinvasion. Patients with squamous histology may not require repeat conization prior to definitive therapy. No factors predict residual disease with adenocarcinoma. In women with AIS with negative margins and ECC and no microinvasion, it appears reasonable to proceed with simple hysterectomy.