کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3942850 1254048 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of close surgical margins after radical hysterectomy for early-stage cervical cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The impact of close surgical margins after radical hysterectomy for early-stage cervical cancer
چکیده انگلیسی

ObjectiveWhile it is known that positive surgical margins increase the risk of cervical cancer recurrence, little is known about the effect of close surgical margins (CSM). Therefore, we set out to determine the impact of margin status on recurrence and survival in patients with early-stage cervical cancer.MethodsA retrospective review was conducted of patients undergoing radical hysterectomy from 2000 to 2010 with Stage IA2-IIA cervical cancer. CSM were defined as ≤ 5 mm; association with other clinicopathologic factors as well as recurrence and survival was evaluated.ResultsOf the 119 patients, 75 (63%) with CSM had a recurrence rate of 24% compared to 9% without CSM. Though not independently associated with recurrence, CSM were significantly associated with positive lymph nodes (44% vs. 18%), positive parametria (33.3% vs. 2.3%), larger tumors (3.5 vs. 2.5 cm), greater depth of stromal invasion (DOI) (84% vs. 33%), and lymphovascular space invasion (LVSI) (61.3% vs. 34.1%). We failed to find an association between adjuvant therapy and recurrence in those with CSM. Exploratory analysis revealed that a surgical margin of ≤ 2 mm was significantly associated with an increased risk of overall recurrence (36% vs. 9%, p = 0.009) as well as loco-regional recurrence (22% vs. 4%, p = 0.0034).ConclusionsSurgical margins of ≤ 5 mm on radical hysterectomy specimens are often associated with other high or intermediate risk factors for recurrence. While not a proven independent risk factor, the distance to surgical margin may warrant further investigation as an intermediate risk factor along with tumor size, DOI and LVSI.


► Close surgical margins (≤ 5 mm) after surgery for cervical cancer are associated with other known risk factors for recurrence.
► Surgical margins (≤ 2 mm) were associated with an increase risk of recurrence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 128, Issue 1, January 2013, Pages 44–48
نویسندگان
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