Racial disparities in survival in malignant germ cell tumors of the ovary

• Histologic subtype of ovarian germ cell tumor varies by race
• The adjuvant treatment of ovarian germ cell tumors does not vary significantly by race.
• African American women with ovarian germ cell tumors have worse 5 year survival when compared to White women.

ObjectiveTo investigate racial disparities with respect to adjuvant treatment and survival in patients presenting with malignant ovarian germ cell tumors (OGCT).MethodsThe National Cancer Database (NCDB) was used to identify women diagnosed with OGCT. Demographic data were abstracted, including stratification by race and histology. Standard univariate and multivariate analyses using logistic regression were performed to describe predictors of adjuvant treatment. Kaplan–Meier and Cox proportional hazards survival methods were used to evaluate racial differences in survival between African American (AA) and white (W) women.ResultsThe study population included 2196 patients, with 1654 (75.3%) W and 328 (14.9%) AA women. Histologic distribution varied significantly by race (p < 0.0001), but neither age nor stage at presentation showed racial differences (p = 0.086 and p = 0.209, respectively). AA received more chemotherapy than W (W: 54.6%, AA: 65.5%, p = 0.008), but in multivariate analysis there was no statistically significant difference in any adjuvant treatment modality. Despite similar treatment, and independent of histology, survival varied significantly by race with 91% (CI 0.89–0.93) five year survival in W patients compared to 84% five year survival in AA (CI 0.8–0.89) (p = 0.02). These disparities were most pronounced in advanced stage disease, with 5 year survival of 84% (CI 0.79–0.89) in W compared to 61% (CI 0.48–0.78) for AA in stage III (p = 0.0002), and 54% (CI 0.42–0.68) compared to 14% (CI 0.03–0.71) for stage IV (p = 0.05).ConclusionsAA with OGCT have significantly worse 5 year survival when compared to W patients despite similar rates and modalities of adjuvant treatment.