کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3943089 | 1254071 | 2011 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen Prevalence of lymph nodes in the parametrium of radical vaginal trachelectomy (RVT) specimen](/preview/png/3943089.png)
ObjectiveIn order to evaluate radicality in fertility preserving surgery in women with early invasive cervical cancer we analyzed the parametrium of specimens of patients treated by radical vaginal trachelectomy for the presence of lymph nodes. We tried to identify morphologic factors associated with the presence of parametrial lymph nodes.MethodsWe analyzed surgical specimens of 112 patients who underwent radical trachelectomy between June 2004 and April 2009 at the Department of Gynecologic Oncology at Charité Campus Benjamin Franklin and Campus Mitte. All parametrial tissue was step sectioned and a total of 1878H&E stained histological sections were analyzed.ResultsIn 8 patients (7.1%) a total of 13 lymph nodes were detected. Five lymph nodes in four patients had been primarily detected by routine histological examination. In one of these patients (0.9%) a 2 mm lymph node metastasis was found. Serial sectioning revealed additional seven lymph nodes in four patients. The thickness of parametrium correlated significantly with the presence of lymph nodes in the parametrium.ConclusionThe presence of small lymph nodes in the parametrium of specimens of radical trachelectomy is low. In patients with early-stage cervical cancer, the incidence of metastasis is less than 1%. Preoperative assessment of the volume of the parametrium may indicate which patients need parametrial resection.
Research Highlights
► Prevalence of lymph nodes in the parametrium of RVT is low.
► Size of parametrium correlates directly with the presence of lymph nodes.
► Only patients with parametrial thickness of ≥ 1 cm may profit from radical trachelectomy.
Journal: Gynecologic Oncology - Volume 121, Issue 2, 1 May 2011, Pages 298–302