کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3943444 1254113 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vascular endothelial growth factor gene polymorphisms in ovarian cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Vascular endothelial growth factor gene polymorphisms in ovarian cancer
چکیده انگلیسی

Background.Polymorphisms within the vascular endothelial growth factor (VEGF) gene, the most important regulator of angiogenesis and vascular permeability, were shown to be independently associated with an impaired prognosis in various malignancies. No data have been reported in ovarian cancer.Methods.In the present multi-center study, we examined three common polymorphisms within the VEGF gene (VEGF + 405G/C, VEGF − 460C/T, and VEGF + 936C/T) in 553 Caucasian patients with ovarian cancer using pyrosequencing.Results.The three investigated polymorphisms did not correlate with any of the investigated clinico-pathological parameters. In univariate and multivariate models, only FIGO stage and patient's age at diagnosis, but not any polymorphism or any haplotype were correlated with patients' overall survival.Conclusions.In our large multi-center study, the investigated VEGF gene polymorphisms were not associated with prognosis in patients with ovarian cancer.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 105, Issue 2, May 2007, Pages 385–389
نویسندگان
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