Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma

This study was focused on the gene expression profiling of HR-HPV(−) and (+) cervical squamous cells and CSCC obtained by cytobrush. We observed gene expression patterns and signaling pathways that permit the investigator to distinguish between benign squamous cervical cells and CSCC with and without HPV infection.