کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3943493 1254118 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Biweekly gemcitabine and cisplatin in platinum-resistant/refractory, paclitaxel-pretreated, ovarian and peritoneal carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Biweekly gemcitabine and cisplatin in platinum-resistant/refractory, paclitaxel-pretreated, ovarian and peritoneal carcinoma
چکیده انگلیسی

Objectives.Synergism between gemcitabine and cisplatin is supported by preclinical and clinical data. The present study explores the efficacy of a biweekly regimen in platinum-resistant/refractory, paclitaxel-pretreated ovarian and peritoneal cancer.Methods.50 paclitaxel-pretreated patients with platinum-resistant/refractory ovarian or peritoneal carcinoma who had previously received paclitaxel chemotherapy, were treated with six cycles of gemcitabine 1000 mg/m2 followed by cisplatin 40 mg/m2 on days 1 and 15, repeated every 4 weeks.Results.The median platinum-free interval (PFI) was 4 months while the median number of previous treatment lines was 2. Chemotherapy was well tolerated. Objective responses were observed in 31.5% of evaluable patients (n = 35). CA125 response was observed in 68% of patients with elevated CA125 (n = 41). Median overall survival (OS) was 13.2 months (95% Confidence Interval, CI: 10.2–16.2) while progression-free survival (PFS) was 4.9 months (95%CI: 3.5–6.4). A PFI of less than 3 months was associated with lower objective response rates (15.8% versus 50%, p = 0.03).Conclusions.Biweekly gemcitabine and cisplatin is feasible for patients with platinum-resistant ovarian or peritoneal cancer and is associated with a favorable toxicity profile. In a population with recent exposure to platinum, a PFI of less than 3 months was the major factor influencing response to chemotherapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 104, Issue 3, March 2007, Pages 580–585
نویسندگان
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