کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3943522 | 1254118 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma Ovarian neuroendocrine carcinoma, non-small cell type, associated with serous carcinoma](/preview/png/3943522.png)
Background.Neuroendocrine carcinoma of the non-small cell type of the ovary is a rare aggressive tumor, interestingly associated with either a surface epithelial tumor or teratoma.Case.A 71-year-old woman presented with a pelvic mass and underwent a total abdominal hysterectomy with a bilateral salpingo-oophorectomy. Pathology examination showed a 6.5 cm in greatest dimension ovarian tumor composed of neuroendocrine carcinoma of the non-small cell type and serous carcinoma. Immunohistochemical studies including keratin 7, WT-1, and neuroendocrine markers demonstrated differences in the two components. Microsatellite instability (MSI) analysis using five polymorphic markers also showed a different pattern in the two components.Conclusion.This is the first report of an ovarian neuroendocrine carcinoma, non-small cell type, associated with a serous carcinoma. Immunohistochemistry and MSI are very helpful in making a definite diagnosis.
Journal: Gynecologic Oncology - Volume 104, Issue 3, March 2007, Pages 747–752