Anti-tumorigenic action of 2-[piperidinoethoxyphenyl]-3-[4-hydroxyphenyl]-2H-benzo(b)pyran: Evidence for involvement of GPR30/EGFR signaling pathway

► K-1 inhibits endometrial cancer cellular growth and tumor xenograft growth via interfering with GPR30/EGFR/ERK1/2 activation. ► Compound showed dual targeting i.e. non-genomic GPR30 signaling and genomic ER signaling in endometrial cancer cells. ► Benzopyran derivative K-1 could serve as a candidate molecule for future development as a chemotherapeutic agent against human endometrial cancer.