کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3944314 1254188 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A controlled study of mental distress and somatic complaints after risk-reducing salpingo-oophorectomy in women at risk for hereditary breast ovarian cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
A controlled study of mental distress and somatic complaints after risk-reducing salpingo-oophorectomy in women at risk for hereditary breast ovarian cancer
چکیده انگلیسی

ObjectivesRisk-reducing salpingo-oophorectomy (RRSO) provides effective protection against ovarian cancer in BRCA mutation carriers and in women at risk for hereditary breast ovarian cancer, but little is known about non-oncologic morbidity after the procedure. We explored mental distress and somatic complaints in women after RRSO compared to controls from the general population.Methods503 women from hereditary breast ovarian cancer families who had undergone RRSO after genetic counseling received a mailed questionnaire. 361 (71%) responded and 338 (67%) delivered complete data (cases). Controls were five randomly allocated age-matched controls per case (N  = 1690) from the population-based Norwegian Nord-Trøndelag Health Study (HUNT-2).ResultsMean age of cases and controls was 54.6 years at survey. Mean time since surgery was 5.3 years (median 6.0). Compared to controls, the RRSO group had more palpitations (p  = 0.02), constipation (p  = 0.01), pain and stiffness (p  = 0.02), osteoporosis (p  = 0.02) and musculoskeletal disease (p  = 0.01) even after adjustments for demographic factors including use of hormonal replacement therapy. The RRSO group had lower levels of depression (p  < 0.001) and total mental distress (p  = 0.002) compared to controls. In multivariate linear regression analyses, RRSO was associated with lower levels of depression (p  < 0.001) and total mental distress (p  = 0.002).ConclusionsIn this controlled observational study, we found more somatic morbidity such as osteoporosis, palpitations, constipation, musculoskeletal disease and pain and stiffness but lower levels of mental distress among women who had undergone RRSO compared to controls.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 113, Issue 1, April 2009, Pages 128–133
نویسندگان
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