کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3944564 | 1254215 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Malignant ovarian germ cell tumor — Role of surgical staging and gonadal dysgenesis Malignant ovarian germ cell tumor — Role of surgical staging and gonadal dysgenesis](/preview/png/3944564.png)
• Staging of ovarian germ cell tumor is associated with a lower rate of recurrence.
• Fourteen percent of patients with ovarian germ cell tumor had XY karyotype.
• Twenty-nine percent of patients with dysgerminoma had XY karyotype.
ObjectiveTo evaluate the effect of comprehensive surgical staging and gonadal dysgenesis on the outcomes of patients with malignant ovarian germ cell tumor.MethodsWe performed a retrospective review of patients with ovarian germ cell tumors who were treated at our institution between 1976 and 2012.ResultsMalignant ovarian germ cell tumors (MOGCTs) were identified in 50 females. The median age was 24 years (range 13 to 49). Of all MOGCT patients, 42% had dysgerminoma, 20% immature teratoma, 16% endodermal sinus tumor, and 22% mixed germ cell tumor. Univariate analyses revealed that the lack of surgical staging (p = 0.048) and endodermal sinus tumor (p = 0.0085) were associated with disease recurrence, while age at diagnosis, ethnicity, and stage of the disease were not. Multivariate analyses revealed that the lack of surgical staging (p = 0.029) and endodermal sinus tumor (p = 0.016) were independently associated with disease recurrence. In addition, 7 patients (14%) had 46 XY karyotype, including 6 with pure dysgerminoma and 1 with mixed germ cell tumor. Five had Swyer syndrome and 2 had complete androgen insensitivity syndrome. Concurrent gonadoblastoma was found in 5 of the patients. No difference was found in the mean age at presentation, stage distribution, or recurrence rate for MOGCT patients with or without XY phenotype.ConclusionsComprehensive surgical staging was associated with a lower rate of recurrence. Fourteen percent of phenotypic females with MOGCT and 29% of those with dysgerminoma had XY karyotype. The clinical outcome of these patients is similar to that of MOGCT patients with XX karyotype.
Journal: Gynecologic Oncology - Volume 134, Issue 1, July 2014, Pages 84–89