کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3944725 1254225 2013 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Detection of cervical cancer recurrence during follow-up: A multivariable comparison of 9 frequently investigated serum biomarkers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Detection of cervical cancer recurrence during follow-up: A multivariable comparison of 9 frequently investigated serum biomarkers
چکیده انگلیسی


• Serum biomarkers SCC-Ag and hsCRP can accurately detect cervical cancer recurrence.
• Adding other biomarkers yielded no significant extra diagnostic quality.
• In select cases, elevated serum levels preceded clinical recurrence.

ObjectiveTo assess the diagnostic accuracy and model the optimal combination of commonly studied serum biomarkers aimed at identifying recurrence in cervical cancer patients.MethodsFrom a systematic literature search, nine biomarkers (CA-15.3, CA-125, CEA, CYFRA 21-1, hsCRP, IL-6, SCC-Ag, TNF-α and VEGF) were selected for a serum analysis. Samples were derived from a historical cervical cancer cohort. Subjects with serum samples stored in a biobank were included when quality criteria were met, and one sample preceding and at least one following primary treatment were available. In case of recurrence, two additional post-recurrence samples were analyzed. Biomarker serum levels were quantified by enzyme linked or chemiluminescence microparticle immunoassays. Logistic regression and receiver operating curve analysis were employed for selection, modeling and comparison on the diagnostic accuracy of the tested biomarkers.Results205 samples were analyzed from 75 subjects, of whom 19 (25.3%) had a recurrence. The area under the curve (AUC) of CA-15.3, CA-125, CEA, CYFRA 21-1, IL-6, TNF-α and VEGF were all < 0.750. Only SCC-Ag and hsCRP were included in the final model with an AUC of 0.822 (95% CI: 0.744–0.900) and 0.831 (95% CI: 0.758–0.905) respectively. Combined AUC was 0.870 (95% CI: 0.805–0.935). Rises in SCC-Ag and hsCRP significantly increased the odds for recurrence. Each ng/ml of SCC-Ag increase, related to an odds ratio (OR) of 1.117 (95% CI: 1.039–1.200). Comparably, the OR for hsCRP (in mg/ml) was 1.025 (95% CI: 1.012–1.038).ConclusionCombined testing of SCC-Ag and hsCRP yields the highest detection rate of disease recurrence during cervical cancer follow-up.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 131, Issue 3, December 2013, Pages 655–660
نویسندگان
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