Longitudinal evaluation of CA-125 velocity and prediction of ovarian cancer

► A new logistic regression model was developed to evaluate CA-125 velocity and other related covariates as predictors of ovarian cancer. ► CA-125 velocity and time interval between baseline and last screening test were significant predictors of ovarian cancer. ► Average velocity (19.749 U/ml/month) of cancer group was more than 500 times average velocity (0.035 U/ml/month) of non-cancer group.