کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3945565 1254273 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Prognosis of ovarian clear cell carcinoma compared to other histological subtypes: A meta-analysis
چکیده انگلیسی

ObjectiveTo compare the survival outcome between clear cell carcinoma (CCC) and other histological subtypes in epithelial ovarian carcinoma (EOC).MethodsFrom January 1974 to February 2011, we identified a total of 31,800 (CCC; 2152, non-CCC; 29648) patients from 12 studies meeting the inclusion criteria.ResultsHeterogeneity tests demonstrated significant between-study variation (I2 = 92.1%) with no significant difference in hazard ratio (HR) for death between CCC and non-CCC (HR; 1.16, 95% CI; 0.85–1.57, random-effects model). Comparing the HR based on stage I + II, and stage III + IV, between CCC and non-CCC, showed that CCC patients had a higher hazard rate for death than those with non-CCC of the ovary (stage I + II; HR; 1.17, 95% CI; 1.01–1.36, stage III + IV; HR; 1.65, 95% CI; 1.52–1.79). In a comparison of CCC and serous EOC, advanced stage (III and IV) CCC only showed a poorer hazard rate for death than serous EOC (HR; 1.71, 95% CI; 1.57–1.86).ConclusionThis analysis suggests that ovarian CCC patients had poorer prognosis than those with other histological subtypes of EOC, especially in advanced EOC stages. Different treatment strategies may be needed for patients with ovarian CCC.

Research highlights
► Clear cell carcinoma had poorer prognosis than other epithelial ovarian cancer.
► Different treatment strategies may be needed for ovarian clear cell carcinoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 122, Issue 3, September 2011, Pages 541–547
نویسندگان
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