کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3945917 | 1254304 | 2009 | 5 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prevention of tamoxifen induced endometrial polyps using a levonorgestrel releasing intrauterine system: Long-term follow-up of a randomised control trial1 Prevention of tamoxifen induced endometrial polyps using a levonorgestrel releasing intrauterine system: Long-term follow-up of a randomised control trial1](/preview/png/3945917.png)
ObjectivesIn a RCT, we have previously shown that the levonorgestrel intrauterine system (LNG-IUS, Mirena®) produces a decidual response protecting the endometrium at one year follow-up. We here report on the long-term follow-up of this group of women, to test the hypothesis that a LNG-IUS could prevent the pro-proliferative uterine responses of tamoxifen for up to 4.5 years.MethodsA randomised-controlled trial of postmenopausal women who had taken at least one year of adjuvant tamoxifen therapy.ResultsOne hundred twenty-two women were recruited. Nine were found to be ineligible after randomisation. The average duration of follow-up was 26.25 months (IQR 14.5–36 months) in the surveillance group and 24.2 months (IQR 13.75–32.5 months) in the LNG-IUS group. Women with LNG-IUS in situ at the time of final assessment had decidualised endometrium, and no polyps. In the surveillance group new polyps arose in 8 cases. There were 3 new polyps in the group initially randomised to LNG-IUS, one in a patient who did not have the device inserted and 2 occurred in patients following the removal of the LNG-IUS. Univariate Cox proportional hazards regression models identified only endometrial thickness at trial entry as a statistically significant variable (HR 1.12, 95% CI 1.02 to 1.22, p = 0.01) for the development of polyps.ConclusionThis study confirms that LNG-IUS induces benign endometrial changes and prevents endometrial polyps but only during its use in women taking tamoxifen. Endometrial thickness is a risk factor for the development of polyps.
Journal: Gynecologic Oncology - Volume 114, Issue 3, September 2009, Pages 452–456