کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3945957 1254308 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
The role of lymphadenectomy in the management of preoperative grade 1 endometrial carcinoma
چکیده انگلیسی

ObjectiveWe sought to assess the accuracy of a preoperative grade 1 designation and role of lymphadenectomy in women with preoperative grade 1 endometrial cancer.MethodsA retrospective analysis of patients diagnosed with preoperative grade 1 endometrial cancer from 1970 to 2006 was conducted. Inclusion criteria were preoperative grade 1 disease and hysterectomy with or without surgical staging.Results581 patients who underwent surgery for preoperative grade 1 cancer were identified. Lymphadenectomy was performed in 46%. Pelvic and aortic node metastases were identified in 5.4% and 3.2% patients who underwent lymphadenectomy. 9.7% were upgraded intraoperatively and 25% were upgraded on final pathology with 22% having grade 2 and 3% grade 3 disease. 22.5% with grade 1 disease intraoperatively were upgraded on final pathology, with 21.1% having grade 2 and 1.4% grade 3 disease. 9% had advanced stage disease. 20% of patients with disease limited to the uterus had adverse features including high risk histologic variants, grade 3 disease, myometrial invasion > 1/2, and/or cervical involvement. After adjusting for risk factors there was no significant difference in OS (HR 1.00, p = 0.992) or PFS (HR 0.96, p = 0.815) between the patients who did or did not undergo surgical staging.ConclusionA substantial number of patients with grade 1 endometrial cancer based on preoperative and intraoperative assessments have higher grade disease on final pathology. Although lymphadenectomy does not affect survival in this group it may identify patients with advanced disease and assist in tailoring adjuvant therapy for those with adverse risk factors.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 112, Issue 3, March 2009, Pages 511–516
نویسندگان
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