کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3945961 | 1254308 | 2009 | 6 صفحه PDF | دانلود رایگان |

ObjectiveLysosomal cysteine protease Cathepsin-B has been implicated in the progression of various human tumours. We examined Cathepsin-B protein levels in endometrial carcinoma patients–mainly post-menopausal–and investigated their possible association with clinical and pathological parameters in order to assess Cathepsin-B's significance as a potential tumour biomarker.MethodsThe indirect immunoperoxidase method was used for Cathepsin-B immunohistochemical staining of 64 paraffin-embedded endometrial tumour tissues, having follow-up period of 18–240 months. Steroid hormone receptors were measured as well. Tissue samples were staged following the FIGO criteria.ResultsPositive Cathepsin-B immunostaining was observed in 27 patients (42.2%) and was significantly associated with the FIGO stage of the disease (p = 0.006), as well as cervical and stromal invasion (p = 0.001 and p = 0.037, respectively) and progesterone receptor status (p = 0.027). Positive Cathepsin-B expression was also inversely related to Disease-free Survival (p = 0.034) and Overall Survival (p = 0.035) in univariate analysis, as well as in multivariate analysis (p = 0.022 and p = 0.035, respectively).ConclusionIncreased Cathepsin-B expression was found to be predictive of more aggressive tumour behaviour over time and can be regarded as an unfavourable and independent tumour marker for endometrial cancer patients with a long follow-up.
Journal: Gynecologic Oncology - Volume 112, Issue 3, March 2009, Pages 531–536