کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3946910 1254391 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
18F-FDG PET/CT can predict nodal metastases but not recurrence in early stage uterine cervical cancer
چکیده انگلیسی

ObjectivesTo evaluate the role of the metabolic characteristics of cervical tumor uptake as predictors of a) lymph node (LN) metastases, b) recurrence, in the preoperative staging of early-stage cervical cancer.Methods89 patients with FIGO stage IB1 and IIA < 4 cm cervical cancer were imaged with FDG-PET/CT before radical hysterectomy and pelvic lymphadenectomy. PET/CT images were analyzed and correlated to histological findings. Maximum and mean standardized uptake value (SUVmax, SUVmean), metabolic tumor volume (MTV), total lesion glycolysis (TLG) of cervical lesions were calculated by an iterative adaptive algorithm. These parameters were correlated to the presence of: a) LN metastases, b) relapse after primary treatment.ResultsOut of the 89 patients who underwent preoperative PET/CT scan for staging purpose, 16 were negative at cervical level: they were all pN0 and without recurrence during follow-up (mean 34.1 ± 14.5 months). In 69 patients MTV and TLG were significantly higher (p = 0.0006 and p = 0.03) in pN1 patients in comparison to pN0 patients, while SUV values did not show significant differences between the two groups. No significant correlations were found between SUVmax, SUVmean, MTV, TLG and the evidence of relapse (mean follow-up 29.2 ± 15.5 months).ConclusionsIn early-stage cervical cancer MTV and TLG correlate with the presence of nodal metastases, but their clinical impact on patients management has to be clarified. The absence of pathological cervical uptake could be a good prognostic factor, while SUVmax, SUVmean, MTV, TLG of the cervical uptake have not been found predictors of recurrence.


► Glucose metabolism of cervix cancer was investigated in early-stages by FDG-PET/CT.
► MTV and TLG are correlated to the presence of nodal metastases; SUV values are not.
► The metabolic features of the cervical lesion do not predict recurrence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 127, Issue 1, October 2012, Pages 131–135
نویسندگان
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