کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3947034 | 1254401 | 2011 | 4 صفحه PDF | دانلود رایگان |

ObjectiveThe aim of this study was to evaluate clinicopathologic characteristics, treatment outcome and reproductive function in women diagnosed with ovarian immature teratoma.MethodsThirty-four women with ovarian immature teratoma stages IA to IIIA were identified and included in this study. Patients were treated at one institution; Princess Margaret Hospital, Toronto, Canada between 1970 and 2005.ResultsThe median age at diagnosis was 25.0 years (range: 9.8–60.2 years). Twenty seven (79%) presented with stage IA disease, 5 (15%) with stage IC, 1 (3%) with stage 2B, and 1 (3%) with stage IIIA disease. Thirteen (38%) of the tumors were found to be grade 1, 12 (35%) grade 2, and 9 (27%) grade 3. Initial management was surgical for all patients: 22 (65%) unilateral oophorectomy, 7 (20%) cystectomy only, and 5 (15%) bilateral oophorectomy (4 with hysterectomy). Fourteen (41.8%) patients received adjuvant therapy. The median follow up was 4.8 years (range 0.2–24.3 years). Four patients recurred (histological grade 2 or 3) within 22 months (87.1% 2-year progression free survival). Only one clinical stage I patient who received adjuvant chemotherapy developed a recurrence. Three of the patients who recurred died from their disease.Eleven patients reported an attempt to conceive resulting in 11 pregnancies in 6 women (3 post chemotherapy).ConclusionThe majority of patients diagnosed with an immature teratoma are cured of their disease. However, grade 2 or 3 tumors are associated with a greater chance of recurrence that can be fatal, predominantly within 2 years of diagnosis.
▶ Thirty-four women diagnosed with ovarian immature teratoma at a single institution. ▶ The majority (94%) presented with clinical stage I disease, 13 grade 1, 12 grade 2, and 9 grade 3. ▶ Four patients recurred (grade 2 and 3) all within 22 months, 3 of whom died from their disease.
Journal: Gynecologic Oncology - Volume 123, Issue 1, October 2011, Pages 50–53