کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3947666 1254465 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prognostic factors in pathologic parametrium-positive patients with stage IB–IIB cervical cancer treated by radical surgery and adjuvant therapy
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Prognostic factors in pathologic parametrium-positive patients with stage IB–IIB cervical cancer treated by radical surgery and adjuvant therapy
چکیده انگلیسی

Objective.The purpose of the present study was to identify prognostic factors and recurrent patterns in pathologic parametrium-positive patients with stage IB–IIB cervical cancers treated by radical surgery and adjuvant therapy.Methods.The patient population consisted of 84 individuals presenting with stage IB–IIB cervical cancers and histologically proven parametrial invasion. All these patients were treated postoperatively with adjuvant external whole pelvic irradiation, combination chemotherapy, or chemoradiotherapy.Results.The 5-year disease-free survival rate was found to be 67.2% and 5-year overall survival rate, 75.4%. Multivariate analysis revealed that vaginal invasion (p = 0.0008), lymph node metastasis (p = 0.002), and non-squamous histology (p = 0.010) were independent indicators of the disease-free survival rates and that the vaginal invasion (p = 0.009) and lymph node metastasis (p = 0.011) were independent prognostic factors for the overall survival rates. The 5-year overall survival rate was approximately 90% for patients without these risk factors. Disease recurrence was observed in 26 patients (31.0%) with a median time of 16.5 months (range, 5–59 months) from the surgery. Hematogenous recurrences, including those in the lung, liver, and bone, were significantly higher in patients with non-squamous cell carcinomas (p = 0.008). Distant lymph node recurrences were significantly higher in patients with positive pelvic lymph node and vaginal invasion (p = 0.004 and p = 0.023, respectively). Pelvic recurrences were significantly higher in patients with vaginal invasion (p = 0.026).Conclusions.Vaginal invasion and lymph node metastasis are independent indicators for disease-free and overall survival rates in pathologic parametrium-positive patients with stage IB–IIB cervical cancer treated by radical surgery and adjuvant therapy. The survival rate is excellent in the patients without these risk factors. Hematogenous recurrence may be evident in patients with non-squamous cell carcinomas.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 105, Issue 3, June 2007, Pages 757–761
نویسندگان
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