کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3949732 | 1600378 | 2011 | 4 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Efficacy of intermittent preventive treatment with sulfadoxine–pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria Efficacy of intermittent preventive treatment with sulfadoxine–pyrimethamine on placental parasitemia in pregnant women in midwestern Nigeria](/preview/png/3949732.png)
ObjectiveTo assess the effect of intermittent preventive treatment with sulfadoxine and pyrimethamine (IPT-SP) on placental parasitemia and maternal and perinatal outcome.MethodsWe compared placental malaria parasitemia during pregnancy and pregnancy outcome in 2 groups of women receiving antenatal care at University of Benin Teaching Hospital. One group was prophylactically treated with IPT-SP and the other was not treated.ResultsThe parasitemia rates for peripheral, placental, and cord blood were 11.9%, 11.4%, and 2.7% in the IPT-SP group (n = 370) and 19.1%, 22.6%, and 6.2% in the control group (n = 371) (P = 0.006, P = 0.002, and P = 0.02, respectively). The treatment reduced the odds of placental parasitemia by 37% (OR 0.63; 95% CI, 0.48–0.81). Peripheral (P = 0.002) and placental (P = 0.001) parasitemia were significantly reduced in the subgroup of women who took 2 or 3 doses of SP. Fewer women (16.2%) in the IPT-SP group than the control group (23.7%) had symptomatic malaria. Anemia at delivery was significantly lower in the IPT-SP group (10.8 vs 1.6%). The risks of abortion, preterm delivery, and low birth weight were also significantly lower in the IPT-SP group.ConclusionIPT-SP is effective in preventing placental parasitemia, and reduces rates of malaria, maternal anemia, abortion, preterm delivery and low birth weight among pregnant women.
Journal: International Journal of Gynecology & Obstetrics - Volume 112, Issue 1, January 2011, Pages 30–33