کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3949907 | 1600114 | 2009 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chromosome Y et spermatogenèse
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
زنان، زایمان و بهداشت زنان
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چکیده انگلیسی
Human Y chromosome evolution has progressively been directed towards a role in sex determination and reproduction. Cytogenetically visible structural abnormalities have determined long arm chromosomal regions which define the AZF factor that contains genes implicated in the spermatogenic process. By using molecular tools, the AZF factor has been subdivided into three loci, AZFa, b and c, the deletion of which leads to specific spermatogenesis impairments due to the loss of particular genes. Most AZF genes are specifically expressed in testis but their functions are far to be known precisely. Partial deletions of AZF regions have been described. Some of them have allowed to define more precise genotype-phenotype relationships whereas others are considered as variants in relation to Y chromosome polymorphism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynécologie Obstétrique & Fertilité - Volume 37, Issues 11â12, NovemberâDecember 2009, Pages 901-907
Journal: Gynécologie Obstétrique & Fertilité - Volume 37, Issues 11â12, NovemberâDecember 2009, Pages 901-907
نویسندگان
C. Ravel, J.-P. Siffroi,