کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3950065 | 1600407 | 2008 | 5 صفحه PDF | دانلود رایگان |
ObjectiveTo assess the usefulness of triple-marker screening for Down syndrome in Venezuela.MethodMaternal serum concentrations of alpha fetoprotein (AFP), beta human chorionic gonadotropin (β-hCG), and unconjugated estriol (uE3) were measured weekly in 3895 women from the 15th to the 20th week of pregnancy. Population-specific likelihood ratios were determined and used to calculate the risk of fetal Down syndrome for each pregnancy.ResultsThe median multiple of the median values for AFP, β-hCG, and uE3 concentrations were 0.69, 2.10, and 0.67 for the affected pregnancies. The likelihood ratio for a positive result was 1:19. The detection and false-positive rates were 69.23% and 5.8%.ConclusionThese findings were consistent with reported data and therefore confirmed triple-marker serum screening as effective and suitable for prenatal care in Venezuela. Latin American governments and Health Agencies should recommend offering this screening method to all pregnant women.
Journal: International Journal of Gynecology & Obstetrics - Volume 103, Issue 3, December 2008, Pages 241–245