Interleukin 1 beta gene polymorphism and risk of cervical cancer

ObjectiveTo determine whether a polymorphism at position + 3953 in exon 5 of the lL-1β gene (IL-1β + 3953), a condition associated with an increased risk for a number of inflammatory diseases, is also involved in the development of cervical cancer.MethodWe isolated DNA from peripheral blood in 150 women with cervical cancer and 200 healthy controls, and IL-1β + 3953 allele polymorphism was determined by polymerase chain reaction.ResultsGenotypes A1/A2 and A2/A2 + A1/A2 were associated with increased risk of cervical cancer (odds ratio [OR], 2.88; 95% confidence interval [CI], 1.78–4.67; P < 0.001 and OR, 2.85; 95% CI, 1.77–4.6; P < 0.001, respectively). The risk in a passive smoker with A2/A2 or A1/A2 genotype was increased more than 5-fold (OR, 5.69; 95% CI, 2.61–12.50; P < 0.001) compared with a nonsmoker with the A1/A1 genotype.ConclusionThis study provides evidence of an association between lL-1β + 3953 polymorphism and risk of cervical cancer.