کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3950778 | 1600316 | 2015 | 4 صفحه PDF | دانلود رایگان |
ObjectiveTo describe high-resolution anoscopy (HRA) findings and compare them with histopathology results.MethodsIn a cross-sectional, observational study performed between December 2008 and December 2009, women receiving care at a center in Recife, Brazil, after a histopathologic diagnosis of cervical intraepithelial neoplasia or cervical cancer were screened for anal neoplasia by HRA. Patients with anal lesions were divided into groups A (metaplasia and/or human papillomavirus infection) and B (anal intraepithelial neoplasia [AIN]). Patients with squamous cell atypia in group A and all patients in group B underwent histopathologic analysis. Agreement between HRA and histopathology findings was estimated for group B.ResultsHRA was done in 324 women, 204 (63.0%) of whom had anal lesions. Overall, 169 cases (82.8%) were classified as group A and 35 (17.2%) as group B. Histopathologic data were obtained for 28 of the 35 group B cases. Histopathology was suggestive of AIN in 19 (67.9%), resulting in a κ coefficient of 0.45 (95% confidence interval [CI] 0.26–0.65; P < 0.001). Relative to histopathology, HRA had sensitivity of 57.6% (95% CI 40.8%–72.7%), specificity of 86.1% (95% CI 75.7%–92.5%), positive likelihood ratio of 4.1 (95% CI 3.1–5.5), negative likelihood ratio of 0.5 (95% CI 0.4–0.5), and accuracy of 76.5% (95% CI 67.2%–83.8%).ConclusionHRA findings can be systematized, reducing the subjectivity of interpretation.
Journal: International Journal of Gynecology & Obstetrics - Volume 128, Issue 3, March 2015, Pages 216–219