A multicenter comparative study of UCu200, TCu380A, and medicated γ-IUD devices inserted immediately after vacuum aspiration

ObjectiveTo compare safety and efficacy among 3 types of intrauterine device (IUD), namely UCu200, TCu380A, and medicated γ-IUD, when inserted after vacuum aspiration.MethodsIn a multicenter randomized comparative study, 1800 parous women requesting an IUD were enrolled in 12 centers across China in 2004–2005. The women received 1 of the 3 types of IUD and were followed-up for 12 months.ResultsAmong the participants, 596 received the UCu200, 591 received the TCu380A, and 594 received the medicated γ-IUD. No pregnancy occurred during the follow-up period. The expulsion rate was 4.13 per 100 women (95% confidence interval [CI], 0.83–5.75) for the UCu200, 5.16 (95% CI, 0.92–6.96) for the TCu380A, and 2.73 (95% CI, 0.67–4.05) for the medicated γ-IUD. The rate of medical removal of the UCu200, TCu380A, and medicated γ-IUD was 3.60 (95% CI, 0.77–5.11), 2.25 (95% CI, 0.62–3.46), and 1.02 (95% CI, 0.41–1.83), respectively.ConclusionImmediate insertion of the device after vacuum aspiration was found to be safe and effective for all 3 types of IUD. Compared with the other IUDs, the medicated γ-IUD had a lower rate of medical removal and might be the most appropriate for broad use.www.chictr.org: ChiCTR-TRC-12002395