Stable mesoporous Fe/TiO2 nanoparticles: A recoverable catalyst for solvent-free synthesis of propargylamine via CH activation

• Fe-doped titania and silica are synthesized with modified sol–gel route.
• Fe bonded with polymeric material and the Fe/P123 mixture was used as template.
• Fe/MO2 used as catalyst for Aldehyde–Alkyne–Amine coupling reaction.
• Excellent yields with good catalyst recyclability was observed.

Fe-doped mesoporous metal oxides (Fe/MO2, M = Si and Ti) were synthesized with particle size in the range of 10–15 nm via modified sol–gel method. The Fe modified SiO2 and TiO2 have proved to be very efficient catalysts in three-component coupling of aldehydes, alkynes and amines for the solvent-free synthesis of proargylamines. Among the two Fe-doped metal oxide catalysts, Fe/TiO2 gives 94% propargylamine yield at 245 W microwave power for few minutes under solvent free condition and found to be a better catalyst. With a Fe/TiO2 heterogeneous catalyst and in the absence of solvent, the proposed process for propargylamine synthesis is green and environmentally benign protocol.

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