کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3951152 1600101 2015 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Hepatoid carcinoma of the ovary: A case report and review of the literature
ترجمه فارسی عنوان
کارسینوم هپاتوئید تخمدان: گزارش مورد و بررسی ادبیات
کلمات کلیدی
کارسینوم تخمدان هپاتوئید، آلفا فتو پروتئین
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


• We present a rare case of primary hepatoid carcinoma of the ovary.
• All thirty-two reported cases in the literature were reviewed and patient and tumor characteristics analyzed.
• All but one primary tumor stained positive for alpha-fetoprotein (AFP).
• Serum AFP and CA125 are typically elevated and have prognostic value.
• Tumor debulking surgery followed by a platinum/taxane based chemotherapy regimen provided some of the most promising outcomes.

Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention, weight loss, and a large lower abdominal mass. Postoperative serum AFP was markedly elevated and trended down with initiation of chemotherapy. Review of the literature revealed thirty-two reported cases with no consensus on histogenesis or consistent immunohistochemical profile other than positive AFP staining in all but one case. Although the optimal treatment has not yet been determined, tumor debulking surgery followed by a platinum and taxane based chemotherapy regimen has shown promise. Both serum AFP and CA125 appear to have prognostic value and can be used to follow response to treatment and screen for recurrence.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology Reports - Volume 13, August 2015, Pages 64–67
نویسندگان
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