کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3952353 1600431 2007 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Topical testosterone versus clobetasol for vulvar lichen sclerosus
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Topical testosterone versus clobetasol for vulvar lichen sclerosus
چکیده انگلیسی

ObjectiveTo compare the effects of topical testosterone and clobetasol treatments on symptoms remission and recurrence rates in patients with vulvar lichen sclerosus (LS).MethodsA retrospective review of the records showed that, of 140 patients with biopsy-proven vulvar LS, 80 were treated with applications of testosterone propionate 2% in petrolatum and 60 with clobetasol 17-propionate 0.05%.ResultsThe response rates after 6 months were 77.5% for patients treated with testosterone and 91.7% for those treated with clobetasol (P = 0.02). The recurrence rates were 20% and 6.7% in the 2 groups, respectively (P = 0.02). Premenopausal patients had higher remission rates and lower recurrence rates than postmenopausal patients (P > 0.05). Considering whole patients, low remission rates and high recurrence rates were observed in patients who had had a hysterectomy (P > 0.05).ConclusionTreatment of LS with a corticosteroid provided excellent remission rates. In this study, clobetasol 17-propionate 0.05% was superior to testosterone for both remission induction and maintenance therapy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Gynecology & Obstetrics - Volume 96, Issue 2, February 2007, Pages 117–121
نویسندگان
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