Goserelin versus leuprolide before hysterectomy for uterine fibroids

ObjectiveTo compare goserelin and leuprolide given before hysterectomy for symptomatic large fibroid uteri.MethodsA randomized study of 66 premenopausal women with fibroid uteri at least 14 weeks of gestation in a gravid uterus. Women were randomized to receive either subcutaneous depot 3.6 mg goserelin or 3.75 mg leuprolide every 4 weeks for a total of 3 doses. Hysterectomy was performed within 1 month of the last dose.ResultsA total of 34 women randomized to the goserelin group and 31 women to the leuprolide group were available for analysis. Preoperative hemoglobin level (P = 0.89), operative blood loss (P = 0.72), and operating time (P = 0.39) were not different between the 2 groups. Postoperative hemoglobin was higher in the leuprolide group (P = 0.003), but blood transfusion requirement was not different between the groups (P = 1.0). Other outcomes and side effects of the drugs were similar.ConclusionsGoserelin and leuprolide administered before hysterectomy for uterine fibroids have similar perioperative outcomes.