کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3952948 | 1600426 | 2007 | 6 صفحه PDF | دانلود رایگان |
Objective:To determine human leukocyte antigen (HLA)-G and interleukin (IL)-10 expression and the relationship between HLA-G expression and clinicopathologic features in patients with cervical cancer.Method:Tissue samples were obtained from 40 patients with cervical cancer and 15 control patients with a normal cervix. Quantitative real-time RT-PCR for mRNA and western blot analysis for protein expression were used.Result:Both HLA-G and IL-10 mRNA expression in cervical cancer tissues was significantly greater than normal controls (P < 0.001, P = 0.005). Protein expression of HLA-G and IL-10 in the cancer group was also significantly greater than in the controls (P < 0.001, P = 0.021). There was an inverse relationship between FIGO stage and HLA-G mRNA expression (P = 0.046).Conclusion:HLA-G and IL-10 might play an important role in cancer progression of the cervix. High HLA-G mRNA expression may be related to early carcinogenesis since it was associated with early-stage cervical cancer.
Journal: International Journal of Gynecology & Obstetrics - Volume 98, Issue 1, July 2007, Pages 48–53