کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3953957 1600419 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Plasmapheresis and pregnancy outcome in patients with antiphospholipid syndrome
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
پیش نمایش صفحه اول مقاله
Plasmapheresis and pregnancy outcome in patients with antiphospholipid syndrome
چکیده انگلیسی

ObjectiveTo assess plasmapheresis with low dose prednisone on obstetric and neonatal outcomes among unsuccessfully treated pregnant women with documented antiphospholipid syndrome (APS).MethodsEighteen pregnant women received prednisone (10 mg/day) and plasmapheresis at 7.08 ± 0.6 weeks of gestation, for 3 sessions per week, until lupus anticoagulant activity suppressed and IgG anticardiolipin lowered. Serial pulsatility indexes (PI) of umbilical and uterine arteries were performed.ResultsThe live birth rate was 100%; mild pre-eclampsia 5.5%; preterm deliveries 22.22%; intrauterine growth restriction 11.11%; thrombocytopenia 5.5%; oligohydramnios and fetal distress 16.6%. There were no perinatal deaths, thrombotic events or lupus flare. Uterine artery PI was reduced and umbilical artery PI was > 95th percentile.ConclusionPlasmapheresis and low dose prednisone were associated with a low rate of obstetric and neonatal complications. Plasmapheresis may be used to treat pregnant women with documented APS when first lines (aspirin and/or heparin) fail to prevent pregnancy loss.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Gynecology & Obstetrics - Volume 99, Issue 3, December 2007, Pages 236–241
نویسندگان
, , ,